H5N1 Viral Sequences Isolated from Patients

Cambodia | China (Hong Kong) | China (mainland) | Djibouti | Egypt | Indonesia | Iraq | Thailand | Turkey | Viet Nam, including Dong Thap cluster

Sequences are from GenBank and The Influenza Sequence Database

  • Cambodia
    • Patient not described
      • Viral sequences
        A/Cambodia/JP52a/2005
        PB2 | PB1| PA | HA| NP | NA | M | NS

  • China (Hong Kong)
    • Patient: 13 year old boy
      • Patient died in 1997
      • Viral sequences
        A/Hong Kong/483/97
        PB2 | PB1| PA | HA | NP | NA | M | NS
      • References 2,3
    • Patient: 5 year old girl
      • Patient recovered in 1997
      • Viral sequences
        A/Hong Kong/486/97
        PB2 | PB1 | PA | HA | NP | NA | M | NS
      • References 2,3
    • Patient: 33 year old man
      • February 07, 2003. Became ill.
      • February 14, 2003. Virus isolated from nasopharyngeal aspirate.
      • February 17, 2003. Patient died.
      • Patient was the father of the 9 year old boy described below.
      • Viral sequences
        A/HK/212/03
        PB2 | PB1 | PA | HA | NP | NA | M | NS
      • References 1
    • Patient: 9 year old boy
      • February 09, 2004. Became ill.
      • February 14, 2003. Virus isolated from nasopharyngeal aspirate.
      • Recovered.
      • Viral sequences
        A/HK/213/03
        PB2 | PB1 | PA | HA | NP | NA | M | NS
      • References 1
    • Patient: 19 year old woman
      • Patient recovered
      • Viral sequences
        A/Hong Kong/542/97
        PB2 | PB1 | PA | HA | NP | NA | M | NS
      • References 10, 11
    • Patient: 3 year old boy
      • Patient recovered
      • Viral sequences
        A/Hong Kong/538/97
        PB2 | PB1 | PA | HA | NP | NA | M | NS
      • References 10, 11
    • Patient: 14 year old girl
      • Patient recovered
      • isolated from nasopharyngeal swab/tracheal aspirate
      • Viral sequences
        A/Hong Kong/532/97
        PB2 | PB1 | PA | HA | NP | NA | M | NS
      • References 10, 11
    • Patient: 2 year old boy
      • Patient recovered
      • Viral sequences
        A/Hong Kong/481/97
        Bender et al sequences
        PB2 | PB1 | PA | HA | NP | NA | M | NS

        Hiromoto et al sequences
        PB2 | PB1 | PA | HA | NP | NA | M | NS

        Shaw et al sequences
        PB2 | PB1 | PA | HA | NP | NA | M | NS

        Lin et al sequences
        PB2 | PB1 | PA | HA | NP | NA | M | NS
    • Patient: 60 year old woman
      • Patinet died
      • Viral sequences
        A/Hong Kong/516/97
        PB2 | PB1 | PA | HA | NP* | NA* | M | NS
      • References 10, 11
  • one of several sequences for this gene and strain

  • China (mainland)
    • Patients: Two women became ill and died in November 2005 in Anhui. One was 24 and the other 35 years old.
      • Viral sequences. No indication of which woman each virus was isolated from.
        A/Anhui/1/2005
        PB2 | PB1 | PA | HA | NP | NA | M | NS

        A/Anhui/2/2005
        PB2 | PB1 | PA | HA | NP | NA | M | NS
    • Patient not described
      • Viral Sequences
        A/human/Zhejiang/16/2006
        PB2 | PB1 | PA | HA | NP | NA | M | NS
    • Patient not described
      • Viral Sequence
        A/Guangxi/1/2005
        PB2 | PB1 | PA | HA | NP | NA | M | NS

  • Djibouti
    • Patient: 8 year old girl
      • No futher information available
      • Viral sequences
        A/Djibouti/5691NAMRU3/2006
        PB2 | PB1 | PA | HA | NP | NA | M | NS

  • Egypt
    • Patient: 30 year old man
      • Patient became ill in 2006.
      • Viral sequences
        A/Egypt/2782-NAMRU3/2006
        PB2 | PB1 | PA | HA | NP | NA | M | NS

  • Indonesia
    • Patient: 38 year old man
      • July 02, 2005. Patient became ill.
      • July 12, 2005. Patient died.
      • Viral sequences
        A/Indonesia/5/05
        PB2 | PB1 | PA | HA | NP | NA | M | NS

  • Iraq
    • Patient: 15 year old girl
      • February 17, 2006. Patient died.
      • Viral sequences
        A/human/Iraq/207-NAMRU3/2006
        PB2 | PB1 | PA | HA | NP | NA | M | NS

  • Thailand
    • Patient: 7 year old boy
      • Patient died in 2004
      • Viral sequences
        A/Thailand/16/2004
        PB2 | PB1 | PA | HA | NP | NA | M | NS
      • References 2,3
    • Patient: 58 year old woman
      • Patient died in 2004
      • Viral sequences
        A/Thailand/3(SP-83)/2004
        PB2 | PB1 | PA | HA | NP | NA | M | NS
      • References 2,3
    • Patient: 6 year old boy
      • Patient died in 2004
      • Viral sequences
        A/Thailand/Kan353/2004
        PB2 | PB1 | PA | HA | NP | NA | M | NS
      • References 2,3
    • Patient: Not described
      • Viral sequences
        A/Thailand/676/2005
        PB2 | PB1 | PA | HA | NP | NA | M | NS
    • Patient: 5 year old boy
      • November 28, 2005. Patient became ill
      • December 07, 2005. Patient died
      • Viral sequences
        A/Thailand/NK165/2005
        PB2 | PB1 | PA | HA | NP | NA | M | NS
      • Reference 6

  • Turkey
    • Patient not described
      • Viral sequences
        A/Turkey/12/2006
        PB2 | PB1 | PA | HA | NP | NA | M | NS
    • Patient not described
      • Viral sequences
        A/Turkey/15/06
        PB2 | PB1 | PA | HA | NP | NA | M | NS
    • Patient not described
      • Viral sequences
        A/Turkey/651242/06
        PB2 | PB1 | PA | HA | NP | NA | M | NS
    • Patient not described
      • Viral sequences
        A/Turkey/65596/06
        PB2 | PB1 | PA | HA | NP | NA | M | NS

  • Viet Nam
    • Patient: 10 year old boy
      • Patient died in 2004
      • Viral sequences
        A/Viet Nam/1203/2004
        PB2 | PB1 | PA | HA | NP | NA | M | NS

        A/Vietnam/1204/2004
        PB2 | PB1 | PA | HA | NP | NA | M | NS
      • References 2,3
    • Patient not described
      • Viral sequences
        A/Hanoi/03/2004
        PB2 | PB1 | PA | HA | NP | NA | M | NS
    • Patient not described
      • Viral sequences
        A/Viet Nam/3046/2004
        PB2 | PB1 | PA | HA | NP | NA | M | NS
      • Reference 3
    • Patient not described
      • Viral sequences
        A/Viet Nam/3062/2004
        PB2 | PB1 | PA | HA | NP | NA | M | NS
      • Reference 3
    • Patient not described
      • Viral sequences
        A/Viet Nam/3212/2004
        PB2 | PB1 | PA | HA | NP | NA | M | NS
    • Patient not described
      • Viral sequences
        A/Hatay/2004
        PB2 | PB1 | PA | HA | NP | NA | M | NS
    • Patient: 14 year old girl
      • February 22, 2005. Became ill.
      • February 27, 2005. Virus isolated from the patient
      • March 14, 2005. Patient discharged from the hospital.
      • Viral sequences
        A/Hanoi/30408/2005
        PB2 | PB1| PA | HA | NP | NA | M | NS
      • References 4
    • Patient not described
      • Viral sequences
        A/Viet Nam/BL-014/2005
        PB2 | PB1 | PA | HA | NP | NA | M | NS
    • Patient not described
      • Viral sequences
        A/Viet Nam/HG-207/2005
        PB2 | PB1 | PA | HA | NP | NA | M | NS
    • Patient not described
      • Viral sequences
        A/Viet Nam/HN30408/2005
        PB2 | PB1 | PA | HA | NP | NA | M | NS
    • Patient not described
      • Viral sequences
        A/Viet Nam/JP14/2005
        PB2 | PB1 | PA | HA | NP | NA | M | NS
    • Patient not described
      • Viral sequences
        A/Viet Nam/JP4207/2005
        PB2 | PB1 | PA | HA | NP | NA | M | NS
    • Patient not described
      • Viral sequences
        A/Viet Nam/JPHN30321/2005
        PB2 | PB1 | PA | HA | NP | NA | M | NS
    • Patient not described
      • Viral sequences
        A/Viet Nam/LA-028/200
        PB2 | PB1 | PA | HA | NP | NA | M | NS
    • Patient not described
      • Viral sequences
        A/Viet Nam/VL-020/2005
        PB2 | PB1 | PA | HA | NP | NA | M | NS
    • Patient not described
      • Viral sequences
        A/Vietnam/CL105/2005
        PB2 | PB1 | PA | HA | NP | NA | M | NS
    • Patient: 26 year old woman from Ho Chi Minh.
      • Patient died on August 5, 2005
      • Viral sequences
        A/Vietnam/CL115/2005
        PB2 | PB1 | PA | HA | NP | NA | M | NS
      • References 7, 8

  • Patient: 35 year old woman from Dong Thap.
    • January 14, 2005. Became ill.
    • January 21, 2005. Patient died.
    • Patient was the mother of the 13 year old girl from whom A/Vietnam/CL2009/2005 was isolated.
    • Viral sequences
      A/Vietnam/CL119/2005
      PB2 | PB1 | PA | HA | NP | NA | M | NS
    • References 7, 8
  • Patient: 13 year old girl from Dong Thap.
    • January 21, 2005. Became ill.
    • January 28, 2005. Patient died.
    • Patient was the daughter of the 35 year old woman from whom A/Vietnam/CL119/2005 was isolated.
    • Viral sequences
      A/Vietnam/CL2009/2005
      PB2 | PB1 | PA | HA | NP | NA | M | NS
    • References 7, 8
  • Patient not described
    • Viral sequences
      A/Viet Nam/DT-036/2005
      PB2 | PB1 | PA | HA | NP | NA | M | NS
  • Patient: 23 year old male from Lam Dong
    • January 2004. Recovered.
    • Viral sequences
      A/Vietnam/CL26/2004
      PB2 | PB1 | PA | HA | NP | NA | M | NS
    • References 7, 8, 9
  • Patient: 8 year old girl from Ho Chi Minh City
    • January 2004. Recovered.
    • Viral sequences
      A/Vietnam/CL01/2004
      PB2 | PB1 | PA | HA | NP | NA | M | NS

References

1. Guan, Y. (2004) H5N1 influenza: A protean pandemic threat. PNAS. 101: 8156–8161. Link

2. Maines et al. (2005) Avian influenza (H5N1) viruses isolated from humans in Asia in 2004 exhibit increased virulence in mammals. J. Virol. 79: 11788–11800. Link

3. Li et al. (2004) Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia. Nature. 430: 209–213. Link

4. Le et al. (2005) Isolation of drug-resistant H5N1 virus. Nature. 437: 1108. Link

5. Lin et al. (2000) Avian-to-human transmission of H9N2 subtype influenza A viruses: Relationship between H9N2 and H5N1 human isolates. PNAS. 97: 9654–9658. Link

6. Chutinimitkul et al. (2006) H5N1 Influenza A Virus and Infected Human Plasma. Emerging Infectious Diseases. 12: 1041–1043. Link

7. Smith et al. (2006) Evolution and adaptation of H5N1 influenza virus in avian and human hosts in Indonesia and Vietnam. Virology. 350: 258–268. Link

8. de Jong et al. (2005) Oseltamivir Resistance during Treatment of Influenza A (H5N1) Infection. NEJM. 353: 2667–2672. Link

9. Tran et al. (2004) Avian Influenza A (H5N1) in 10 Patients in Vietnam. NEJM. 350:1179–1188. Link

10. Bender et al. (1999) Characterization of the surface proteins of influenza A (H5N1) viruses isolated from humans in 1997–1998. Virology. 254: 115–123. Link

11.Shaw et al. (2002) Molecular changes associated with the transmission of avian influenza a H5N1 and H9N2 viruses to humans. J. Med. Virol. 66: 107–114. Link

See also H5N1 Hemagglutin Sequences

Page last modified on July 25, 2006, at 09:27 AM by Monotreme